منابع مشابه
Concomitant presence of p16/cyclin-dependent kinase 4 and cyclin D/cyclin-dependent kinase 4 complexes in LNCaP prostatic cancer cell line.
The cyclin D/cyclin-dependent kinase (CDK)/CDK-inhibitory proteins/retinoblastoma protein (pRb) pathway is hypothesized to control the G1-S check point. The role of this pathway is reported to be different depending on the status of pRb. In the present study, we examined nine human urological tumor cell lines. Cells lacking functional pRb expressed p16, instead of forming cyclin D/ CDK4 complex...
متن کاملHomozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias.
Recently, it has been shown that the homozygous deletion of the cyclin-dependent kinase-4 inhibitor (CDK4I;p16) gene, which is mapped to chromosome 9p21, is frequently observed in a wide spectrum of human cancers, including leukemias. Therefore, the CDK4I gene is thought to be a putative tumor-suppressor gene. We report here that both alleles of the CDK4I gene were completely or partially delet...
متن کاملTumor Suppressor p16: Determination of Solution Structure and Analyses of Its Interaction with Cyclin-Dependent Kinase
to a variety of cellular proteins such as NF-B and IB (Hirai et al., 1994; Suzuki et al., 1996). Figure 1 shows the primary sequence of p16, along with that of other proteins in the p16 family: p15, p18, and p19, both human and murine. P16 is comprised mainly of four ankyrin repeats, a structural motif about Campus Chemical Instrument Center 33 amino acids long present in a variety of protein...
متن کاملDeletion of cyclin-dependent kinase 4 inhibitor genes P15 and P16 in non-Hodgkin's lymphoma.
B-cell non-Hodgkin's lymphoma (NHL) is a heterogeneous lymphoid malignancy consisting of several histologic types. Alterations in proto-oncogenes caused by reciprocal chromosome translocations have been implicated in the etiology of specific histologic groups. In this study, we examined the contribution of the cell cycle inhibitor genes P15, P16, and P18 to pathogenesis in a large panel of 209 ...
متن کاملp16 Mediates Cyclin Dependent Kinase 4 and 6 Inhibition in Senescent Prostatic Epithelial Cells
The senescence checkpoint constrains the proliferative potential of normal cells in culture to a finite number of cell doublings. In this study, we investigated the mechanism of cyclin dependent kinase (cdk) inhibition in senescent human prostatic epithelial cells (HPECs). Progression of HPECs from early passage to senescence was accompanied by a gradual loss of cells in S phase and an accumula...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/38121